Acute Dialysis Quality Initiative 4 th International Consensus Conference
نویسندگان
چکیده
Iatrogenic acute kidney injury can be defined as acute kidney injury (AKI) that is directly or indirectly due to medical (therapeutic or diagnostic) interventions. This definition does not imply that iatrogenic AKI is always preventable. Indeed, sometimes the need for the medical intervention outweighs the risk of causing kidney dysfunction. On the other hand, in many circumstances iatrogenic renal damage can be prevented or at least minimized. In hospitalized patients reported incidences of iatrogenic AKI vary between 1 and 3% [1,2]. Although therapeutic interventions, such as certain surgical procedures (cardiopulmonary bypass, aortic cross clamping) or intensive care treatments (mechanical ventilation) may also contribute to renal impairment, drug nephrotoxicity is the main cause of iatrogenic kidney dysfunction. 20-60% of all cases of AKI are considered drug-related [3,4]. The exact incidence of nephrotoxicity associated with a particular drug is difficult to determine because of the lack of uniformity in defining the criteria for renal dysfunction and the poor literature that is mostly limited to clinical series and case reports, often restricted to patients with risk factors.
منابع مشابه
Acute Dialysis Quality Initiative 4 th International Consensus Conference
Primary prevention of acute renal failure (ARF) refers to clinical strategies which reduce the occurrence of ARF in patients with or without underlying chronic renal disease who do not yet exhibit evidence of acute renal dysfunction or injury. The lack of sensitive measures of renal injury (biomarkers) as well as the difficulty in assessing renal function in a “non-steady state” condition has l...
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4. Newsome BB, Warnock DG, McClellan WM et al. Long-term risk of mortality and end-stage renal disease among the elderly after small increases in serum creatinine level during hospitalization for acute myocardial infarction. Arch Intern Med 2008; 168: 609–616 5. Coca SG, Yusuf B, Shlipak MG et al. Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic rev...
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